![]() Withdrawal of an antidepressant is also indicated after an episode of depression has been adequately treated - usually six to nine months after recovery from a single episode. 5 Switching from one antidepressant to another is a common clinical challenge. 4 Unacceptable adverse effects from antidepressants, such as sexual dysfunction and weight gain, may also necessitate a change of therapy. 3 There is no evidence that switching between classes of antidepressants is more effective than switching within a class. 2 About a quarter of patients switched to a second antidepressant can be expected to achieve remission. ![]() 1 A patient is unlikely to respond if there has been no improvement after three to four weeks on an adequate dose of antidepressant. After assuring correct diagnosis, optimal dose, duration and adherence to treatment, a change of antidepressant drug is indicated. ![]() Up to two-thirds of patients with major depression fail to respond to their first antidepressant drug. ![]() These can be divided into 13 clinically relevant groups, which differ substantially in their pharmacodynamic and pharmacokinetic characteristics. There are over 20 antidepressants currently available in Australia. Antidepressant drugs are indicated for the treatment of depression, anxiety disorders (including panic and social phobia), obsessive compulsive disorder and post-traumatic stress disorder. ![]()
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